Analysis were analyzed by about three-way ANOVA that have pairwise review followed closely by Tukey’s post hoc sample


The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical parameters

Imply SBP prior to urinary sodium so you can potassium (Na + /K + ) excretion proportion during assessment sufficient reason for slimming down input of Dietary Solutions to Stop Blood pressure levels (DASH) higher sodium (HS) and you will lowest sodium (LS) eating plan inside (a) sodium painful and sensitive (letter = 71), (b) salt resistant (n = 119) people, philosophy found given that imply ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Next, several research has ideal that the blood pressure levels prevention evoked of the K + consumption could be dependent on weightloss Na + intake [twenty eight, 29]. Inside our investigation of your own Dash-Sodium dataset i seen zero relationship having urinary K + excretion and you will SBP, inside diligent assessment see or during the Dash dieting input whenever Na + intake are changed, indicating an independence of effects of Na + and you can K + into SBP in this study. The brand new 2019 DRI Statement determined that there can be diminished evidence towards the effects away from K + towards blood pressure levels and you will failed to introduce a great DRI away from K + . The research keep the 2019 DRI Statement and shows that weight reduction K + supplementation will most likely not rather dump blood circulation pressure regarding the standard society.


Stamler J, Flower G, Stamler R, Elliott P, Dyer A beneficial, Marmot Yards. INTERSALT study results. Personal health and health care ramifications. Blood pressure. 1989;–7.